The student is expected to have knowledge of the content of the following B.Sc. level courses: Principles of Genetics and 529054 Tieteellisen laskennan perustaidot or the book Klug, Cummings, Spencer, Palladino: Concepts of Genetics. Pearson. 2011
After this course the student will have knowledge of the genome structure at the chromosome and DNA levels, and conservation of genomes between different organisms, including both prokaryotes and eukaryotes. The student will be familiar with the modern methods to investigate genome sequence and structure, including DNA sequencing, molecular cytogenetics and karyotyping. The student will know which kind of variation exists between individuals and how this variation affects normal and disease phenotypes. Through exercises that are carried out independently and during the lectures the student will strengthen his/her problem-solving skills.
Every year period 3, recommended at the first year of M.Sc. studies.
The course topics include:
- Genome structure at the chromosome and DNA levels, conservation between organisms (prokaryotes, animal eukaryotes, and plant eukaryotes), and chromatin structure.
- Cytogenetics, including karyotype analysis, common numerical and structural chromosome aberrations, and molecular cytogenetics, such as fluorescent in situ hybridization.
- DNA variation and its consequences, including variant types (single nucleotide polymorphisms, microsatellites and copy number variation) and extent of polymorphism between individuals.
- Modern methods to investigate the genome, including DNA sequencing and array comparative genomic hybridization.
To pass this course the student will need to successfully carry out exercises and pass the exam.
The course includes ~24 hr of lectures, an exam, and 109 hrs of independent study (including exercises before each lecture).
Course material provided at lectures and for independent studying between lectures.
Grading is on scale 0-5 and is based on the exam.
(Associate professor Iiris Hovatta) Spring 2019 and 2020 Katarina Pelin
Replaces the former course 529025 Mammalian genomics (theory) 3 cr.