The student is expected to have basic knowledge of gene structure, gene regulation, transcription and translation (Alberts level).
After the course the student will be able to recognize and describe the key concepts and terms related to gene regulation and epigenetics and the role of these processes in cell differentiation, development and pathophysiology. The student will also be able to discuss gene regulation at the global level, including the interrelationships between different regulatory levels. Through understanding the principles of the most common experimental approaches, the student will be able to analyze data presented in original research articles in the field.
First year spring.
The course focuses on the mechanisms and regulation of gene expression at different levels. Particular emphasis is on transcriptional regulation, the structure and function of transcription factors, cofactors and regulatory elements, mRNA processing and modifications, transport and mRNA turnover, the role of non-coding RNAs, and translational regulation. The course will also cover basic principles of epigenetic events, such as DNA methylation, histone modifications, histone variants and chromatin remodelling. The key experiments and research approaches within each field will be introduced to the students.
In order to pass the course the student has to pass the final exam and complete an independent writing assignment.
Recommended reading includes:
- Latchman: Gene control
- Allis et al.: Epigenetics
The student will be assessed with the final grading 0-5. The grading is based on the final exam (80%) and the independent writing assignment (20%).
Replaces two of the former courses:
- 52936 Eukaryoottien geenisäätely 3 cr
- 529026 Gene regulation 3 cr
- 529014 Epigenetics 3 cr
- 529232 mRNA processing in eukaryotes 3 cr