The student is expected to be have basic knowledge of principles of developmental biology including basics of gene expression regulation and cell signaling; fertilization; gastrulation and patterning of the embryo; cell polarity, migration and apoptosis; and to be acquainted with the most common model organisms and research methods used in developmental biology research.
Recommended background reading is e.g. Gilbert and Barresi, Developmental Biology (Sinauer).
- The objective of this lecture series is to give the student a thorough view of the development of different organs.
- The student will be able to describe the similarities in development and the special features of different organs.
- A crucial part is to learn how different genes and signaling pathways guide organogenesis.
- The student will also get acquainted with a number of different tissue-specific stem cells, how they regulate tissue homeostasis, and their contribution to stem cell based therapies.
Spring term, period III (1st year of GMB studies).
- Principles of organogenesis: induction, patterning, morphogenesis and differentiation in several different ectodermal, mesodermal and endodermal organs.
- Principles of stem cell biology: definition and self-renewing principles of embryonic stem cells, induced pluripotent stem cells, and adult stem cells in different tissues.
- Gene regulatory networks in development.
The course consists of an obligatory pre-assignment (20%), whose nature may vary from year to year (e.g an essay based on a review article), and lectures and exam (80%). Approx. 30h of lectures, and approx. 100h of independent work. The student has to return the pre-assignment work in order to be eligible to take and pass the exam.
Material provided on the course. Recommended reading: Gilbert and Barresi, Developmental Biology (Sinauer).
Grading is based on the pre-assignment (0-5) and exam (0-5). Exam is based on lectures, and may also include book chapters and articles indicated by lecturers. It is not possible to pass the course without the pre-assignment work.
Docent Marja Mikkola (Institute of Biotechnology, firstname.lastname@example.org)
This course is recommended before the laboratory course Methods in functional genetics and development.
Replaces the former course 529237 Stem cells and organogenesis 4 cr.