The course aims to cover current advances in RNA processing, modifications, localization and translational regulation, and the role of these processes in the development and in disease, including neurological diseases. It will consist of lectures by local and invited expert scientists (two days), and a workshop session (half-day) for about 30 registered students divided in 6 peer groups working to prepare a 15 min presentation summarizing a given research topic from lectures and publications.
After completion of the course, the students are expected to
- outline cellular mechanisms regulating transcription and processing of mRNA and non-coding RNA
- describe the role of non-coding RNAs in development, cellular stress response, and neurological diseases
- evaluate the effects of deregulated RNA processing and biogenesis on cellular stress and survival
- explain how understanding of RNA biology can help to develop new therapies for neurodegeneration diseases
Days 1 and 2: lectures (45 min + questions) by local experts and invited speakers, followed by 30-40 min wrap-up discussion at the end of each day.
Instructors and topics:
Iiris Hovatta: Genome-wide mRNA and miRNA transcriptomic in the brain
Mikko Frilander: Regulation of mRNA processing
Peter Sarin: tRNA modifications and stress response
Susana Garcia: Non-coding repeats and RNA toxicity in neurodegenerative disorders
Marina Vidaki: Local mRNA translation during neuronal development
Andrii Domanskyi: Role of microRNAs in cellular stress and neurodegeneration
Day 3: workshop on RNA biology for registered students. Before and during the course, the students will get several research articles recommended by each speaker. Before the workshop, the students will select a research topic from the course lectures and read corresponding article(s). During the workshop day, working in small groups, the students will prepare and make a 15-20 min presentation on the course content.
Attendance of all lectures during two days: one study credit.
Attendance of all lectures and participation in the workshop: two study credits.
Attendance of all lectures and participation in the workshop and making a presentation: three study credits.
Final exam on course content.
A special attention will be given to students’ abilities to critically read and recognize main conclusions, prepare a concise and logical presentation, actively participate in discussion, and ask meaningful questions.
Academy Research Fellow, PI Andrii Domanskyi