Kaisa_2012_3_photo by Veikko Somerpuro

Enrol
9.2.2020 at 08:00 - 8.3.2020 at 23:59

Description

Course belongs to the Master's program in Chemistry and Molecular Sciences and it is compulsory in the Radiochemistry course block.

KEM313 Nuclear spectrometry AND

KEM316 Chemistry and analysis of radionuclides OR/AND KEM317 Radiopharmaceutical chemistry

Upon completion of the course the student shall be able to:

  • build and set up a measurement system for nuclear energy spectrometry
  • assess the fitness of different analysis methods for measurement of a given radionuclide
  • explain factors affecting the measurement uncertainty and minimize them
  • describe and plan appropriate pretreatment method for environmental samples
  • carry out typical chemical separation methods of radionuclides
  • describe general procedures for production of radiopharmaceuticals
  • understand typical quality criteria for radiopharmaceuticals and do routine QC in practice
  • work independently in a radionuclide laboratory
  • communicate obtained results in scientific language in written and oral form

First year of the Master's program and/or before starting the Master's Thesis work in radiochemistry.

The course is offered annually in Period IV.

The course consists of radiation measurement exercises common to all the students (KEM314A) and laboratory exercises that are aligned to students based on their completion of KEM316 (KEM314B) or/and KEM317 (KEM314C).

Radiation measurement (KEM314A):

  • measurement signal processing
    • energy spectrometry
    • time spectrometry
  • alpha spectrometry
    • semiconductor detectors
  • gamma spectrometry
    • scintillation and semiconductor detectors
    • interpretation of gamma spectra
  • liquid scintillation spectrometry
    • alpha/beta discrimination
  • principle of coincidence detection

Chemistry and analysis of radionuclides (KEM314B)

  • special features of radiochemical analyses
    • yield tracing with stable and radioactive tracers
    • use of isotopic and non-isotopic carriers
  • sample preparation
    • microwave assisted wet digestion
  • radiochemical separation methods
    • precipitations
    • anion and cation exchange
    • extraction chromatography
    • deposition

Radiopharmaceutical chemistry (KEM314C)

  • radionuclide generators
  • production of radionuclides with cyclotrons
  • labelling with short-lived positron emitters
    • typical labelling procedures
    • operation of automated synthesis unit
    • formulation of the final product
  • quality control of radiopharmaceuticals
    • identification of the product
    • radionuclidic, radiochemical and chemical purity
  • in vitro evaluation of radiopharmaceutical properties

Essential material will be delivered during the course (via Moodle). Recommended textbooks for further reading include:

  • G.J. Knoll: Radiation Detection and Measurement, Fourth Edition, Wiley, 2010
  • J. Lehto and X. Hou: Chemistry and Analysis of Radionuclides, VCH-Wiley, 2011
  • S. Vallabhajosula: Molecular Imaging: Radiopharmaceuticals for PET and SPECT, Springer, 2009

The course (5 cr) consists of 135 hours of student work, including:

  • 3 h of lectures
  • 40-60 h of measurement and laboratory exercises
  • 2-4 h of seminars
  • 70-88 h of independent (and group) work

The students are assessed based on their working in laboratory during the exercises, the work reports and participation in seminars at the end of the course. Scale is pass/fail.

The course is completed by active participation in introductory lectures, laboratory exercises and seminars. Some laboratory exercises include also work reports.

In the exceptional case of absence the student will complete assignments to make up for the absence.