Students of the Master’s Programme in Translational Medicine, other Master’s and doctoral students
The student will be able to describe and discuss the essential topics and concepts in bacteriology, virology, parasitology and immunology, and their relation to selected human diseases.
Period IV. The course is arranged every second year (spring 2018 and 2020).
Basic morphology, taxonomy, the genetics and metabolism of bacteria, microbial ecology including human normal flora, interaction between bacteria and eukaryotic cells, pathogenicity and virulence factors
Therapy: The function of antibiotics at the molecular level, diagnostic methods, vaccines against bacterial infections
Bacteria and disease association themes: Bacterial CNS infections, pneumonia, TB, urinary tract infections, sepsis (TNF-alpha cytokine storm)
The structure, classification and replication of viruses, general viral pathogenicity, virus genetics and evolution, general diagnostic methods, antiviral therapy, viruses and the immune system (e.g., viral immune evasion), vaccines against viral infections
Viruses and disease association themes: Emerging viruses, viral respiratory tract infections, influenza, viral gastroenteritis, hepatitis, HIV
The life cycle and pathogenicity of parasites, therapy and clinical parasitology, general diagnostic methods
Parasites and disease association themes: Malaria, helminth infections and the immune response (Th2), vaccines against parasitic infections
General functions of the cells, proteins and organs of the immune system; the maturation, interaction and regulations of innate and adaptive immune responses; clinically oriented immunology: autoimmunity, allergy and transplantation; vaccines: development (phases) and technology (conjugates, genome-based and DNA vaccines, live vaccines, complications etc.)
Immune system and disease association themes: Complement and inflammatory diseases, antibodies as mediators and markers of disease, T cells in health and disease, cytokines
Recommended background reading:
Gillespie and Bamford: Medical Microbiology and Infection at a Glance, 3rd ed., Blackwell, 2007 (now the 4th Edition, 2012, is available)
Murray, Rosenthal and Pfaller: Medical Microbiology, 6th ed., Elsevier, 2009 (the 8th Edition, 2015, is now available)
Irving, Boswell, Ala’Aldeen: Instant Notes in Medical Microbiology, Taylor & Francis, 2005 (the 2nd Edition, 2006, is now available)
Murphy, Travers, Walport: Janeway’s Immunobiology, 7th ed., Garland Science, 2008 ()I have not found any later Editions, thus the 7th would be our choice).
Student activities: Attending the lectures, active participation and a presentation in the seminar. The teachers give lectures, participate in discussions and seminars, arrange question and answer sessions, etc.
Course evaluation is based on the exam (covering bacteriology, virology and parasitology) (100%). Grading scale 0–5
Responsible teachers are doc. Alexander Plyusnin and doc. Tarja Sironen
Completion requires 75% attendance in lectures, attendance and an acceptable presentation in the Immunology seminar, and a passing grade on the exam.
Lectures 42 h
Seminar 4 h
Preparation of a presentation 17 h
Independent study 70 h
Exam 2 h
Total 135 h
Replaces course 30497 Infection Biology